Synthetic joint lubricant could potentially treat osteoarthritis

08/07/2019

Treating osteoarthritis with synthetic joint lubricant may become a reality. The lubricant, currently in canine clinical trials, shows promise for eventual use in humans, claims a study. The treatment, developed by Cornell University biomedical engineers, is a synthetic version of a naturally occurring joint lubricant that binds to the surface of cartilage in joints and acts as a cushion during high-impact activities, such as running. "When the production of that specific lubricant goes down, it creates higher contact between the surfaces of the joint and, over time, it leads to osteoarthritis," said David Putnam, a professor in the College of Engineering.
The study published in 'Proceedings of the National Academy of Sciences' focuses on a naturally occurring joint lubricant called lubricin, the production of which declines following traumatic injuries to a joint, such as a ligament tear in a knee. The knee is lubricated in two ways - hydrodynamic mode and boundary mode.
Hydrodynamic mode lubrication occurs when the joint is moving fast and there isn't a strong force pushing down on it. In this mode, joints are lubricated by compounds like hyaluronic acid (HA) that are thick and gooey, like car oil. There are numerous HA products in the market, approved by the Food and Drug Administration, for treating hydrodynamic mode lubrication disorders. But HA is ineffective when strong forces are pushing down on the joint, such as those that occur during running or jumping. In these instances, thick gooey HA squirts out from between the cartilage surfaces, and boundary mode lubrication is necessary. Under these forces, lubricin binds to the surface of the cartilage. It contains sugars that hold on to water, to cushion hard forces on the knee. The researchers described a synthetic polymer they developed that mimics the function of lubricin and is much easier to produce. "We are in clinical trials, with dogs that have osteoarthritis, with our collaborators at Cornell's College of Veterinary Medicine," Putnam said.
"Once we finalise the efficacy study in dogs, we will be in a very good position to market the material for veterinary osteoarthritis treatment," Putnam said. From there, the human market for a lubricin substitute should follow, just as HA has been made available for human use, mainly in knees.

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